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A University of California, Irvine, spin-out, Modulated Imaging, developer of medical imaging technology based around structured light illumination, has now raised $2.9 million in Series A round of venture funding.
Backed by the investment wings of Japan’s Hamamatsu Photonics and Mitsubishi, alongside Grey Sky Venture Partners and Fresenius Medical Care Ventures, the company is aiming to target a range of medical, aesthetic and research applications with a technique called spatial frequency domain imaging (SFDI). A key potential application of this is identifying diabetes patients likely to develop foot ulcers resulting from poor vascular circulation – side-effects that often go undiagnosed until expensive treatment, and in some cases even amputation, is necessary.
In addition to the venture funding, the company said it also received a $1.2 million “commercialization readiness” grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the US National Institutes of Health (NIH). According to a US Securities & Exchange Commission (SEC) filing in August, the company had been seeking up to $4 million in equity finance.
David Cuccia, whose UC Irvine research forms the basis of the SFDI technique, is both CEO and CTO of Modulated Imaging. According to him, the current infusion of funds allows them to take their imaging technology to the next level, supporting key clinical studies and the development of our next-generation Ox-Imager technology.
Modulated Imaging announced earlier this year that the US Food & Drug Administration (FDA) had approved its Ox-Imager CS product, which is designed to help diagnose lower-limb vascular issues such as diabetic foot ulcers. The SFDI technique is able to identify the likely onset of these potentially dangerous lesions, before they actually develop.
Patients with diabetes often do not realize that they have a problem until the ulceration has reached a critical stage. Modulated Imaging’s technology can measure peripheral perfusion, and allow primary care doctors to screen subjects and prescribe preventative measures prior to ulcer formation. Cuccia, who says that the approach could potentially save more than $6 billion in ulcer treatment annually, added that clinical studies already taking place in California and Arizona will now expand to other locations. A miniaturized version of the Ox-Imager CS system is also under development, and work on that is set to accelerate thanks to the latest venture cash.
The SFDI approach initially developed through a series of small business innovation research (SBIR) grant awards, works by measuring tissue oxygenation saturation from oxy- and deoxy-hemoglobin levels, which are in turn determined according to their relative absorption and reflection of different wavelengths.
Aside from Cuccia, the Modulated Imaging board includes Bruce Tromberg, Director of UC Irvine’s Beckman Laser Institute and Medical Clinic. Alongside Gabriela Apiou from the Harvard Medical School, Tromberg also co-chairs a conference dedicated to translational research within the BiOS symposium at SPIE’s annual Photonics West event.
Originally housed within UC Irvine’s “Photonic Incubator”, in 2014 the expanding company moved to its first commercial space in San Juan Capistrano, but quickly outgrew that location as well and now operates out of a 6000 square foot building in Irvine.