The Orbitrap Fusion Lumos Tribrid from Thermo Fisher Scientific is a Quadrupole Mass Spectrometer that has a mass range of 50 m/z - 6000 m/z. It has a resolving power of 500000 FWHM & 240000 FWHM (isotopic fidelity) (at 200 m/z) and scan rate of up to 30 Hz & 40 Hz. This spectrometer has a dynamic range above 5000 and mass accuracy below 1 ppm RMS (internal) & 3 ppm RMS (external). It has a multiplexity of less than 10 precursors/scan and maximum polarity switching of 1.1 s. This spectrometer has a segmented Quadrupole mass filter and an advanced active beam guide.

The Orbitrap Fusion Lumos Tribrid uses a high-capacity transfer tube, electrodynamic ion funnel, advanced Quadrupole technology, advanced vacuum technology, and high dynamic range Electron Transfer Dissociation (ETD HD). It requires an AC supply voltage of 120 V or 230 V and consumes 15 A of current. This spectrometer is available in a rugged design that measures 1270 (W) mm x 767 (D) mm x 703 (H) mm and is ideal for low-level PTM analysis, multiplexed relative quantitation, intact protein characterization, and analysis of small molecules.