The Clinical and Translational Biophotonics (CTB) conference will focus on research that has demonstrated human clinical applications, such as bioimaging or biosensing of human tissue specimens, first-to-human investigations of new optical imaging technologies for disease detection, diagnosis, or monitoring, clinical studies, and larger clinical trials. Biomedical optics and biophotonics research involving pre-clinical animal models or fundamental technology research should be submitted to other conferences at this congress.