The SPIE Translational Biophotonics + Additive Manufacturing for Photonics 2022 is a co-located meeting merging translational biophotonics and applications, and novel additive manufacturing technologies in any area of photonics. At the University of Southern California's Michelson Center, leaders in the field will discuss paths that led to their advancements and will also plot new directions for the future of optical imaging and photonics for both research and clinical applications. Clinicians will present their perspectives on application needs, while industry representatives will discuss pathways to commercialization.