The Optical Manipulation and its Applications 2023 will take place in Hyatt Regency Vancouver, Vancouver, British Columbia, Canada from 24th April to 27th April 2023. This meeting covers the range of optical manipulation technologies currently being developed for studies in biophysics, single molecule, single cell, and tissue level analysis, optical manipulation of chemical processes in organisms, lab-on-a-chip development, optomechanical cooling, environmental monitoring, and theoretical underpinnings. Technologies to be considered include optical tweezers and associated techniques, photo-activated materials, optogenetics, light-activated drugs and probes, and microfluidics.