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Noninvasive Measurement of Cerebral Blood Flow (CBF) Autoregulation (AR) and Intracranial Pressure (ICP) with Rheoencephalography (REG)

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Noninvasive Measurement of Cerebral Blood Flow (CBF) Autoregulation (AR) and Intracranial Pressure (ICP) with Rheoencephalography (REG)

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It has been documented that space flight increases ICP, causes space flight-associated neuroocular syndrome, damages CBF AR, causing orthostatic intolerance, headache, and impaired neurocognitive performance of astronauts. Research attention was focused on ICP and not on CBF. The cerebrovascular function was mentioned for the first time only in the 2019 solicitation. REG is a noninvasive method to study CBF and its AR. A recent clinical study demonstrated that REG pulse wave morphology shows identical alteration as ICP by reflecting ICP elevation. Miniaturized REG device is available today.

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