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Reverse Translation Strategies to Support Cognitive and Behavioral Risk Characterization

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Reverse Translation Strategies to Support Cognitive and Behavioral Risk Characterization

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  • Author: Gregory Nelson, Janice Zawaski, and S. Robin Elgart
A coordinated suite of measurements to assess humans and animals needs to be established to support the translation and harmonization of animal research data to the astronaut corps due to the necessity of using animal subjects for radiation testing. The identification of POLs and PELs for spaceflight stressors (i.e. space radiation, altered gravity, isolation and confinement, sleep disruption) individually and combined will depend on defining scaling factors or transfer functions that can be used to relate human and animal outcomes.

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