using a PhotoniQ in a DNA Sequencer
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using a PhotoniQ in a DNA Sequencer
DNA sequencing applications require the use of four or more photomultiplier tubes to detect the fluorescence from DNA fragments labeled with fluorescent dyes-each dye indicating the presence of a DNA fragment with one of the four DNA bases. The PMTs are positioned with the optics to detect the fluorescence from the DNA fragments labeled with the individual dye markers. Each PMT connects to a charge sensitive preamp input on a PhotoniQ IQSP418 or IQSP518 multichannel PMT data acquisition system. The data acquisition system is triggered to coincide with the firing of the excitation laser such that each event consisting of the integrated outputs from the four PMTs, is digitized and recorded by the unit.
