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In-Vivo imaging in NIR-II / SWIR (600-1700nm)

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In-Vivo imaging in NIR-II / SWIR (600-1700nm)

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Researchers detecting in the 500-900 nm range suffer from shallow imaging depth and high background due to light scattering and tissue autofluorescence. Over the last five years there has been a growing interest in NIR-II/SWIR imaging detecting in the 1000-1700 nm range to greatly suppress these effects, affording single cell resolution at ~ 3 mm depth and useful resolving power at up to ~ 1 cm depth This interest has been fuelled by the development of NIR-II markers / probes (molecules, carbon nanotubes, quantum dots and rare-earth down-conversion nanoparticles) which provide a great combination of sensitivity, inherent biological safely, and relative ease of use. (see Nirmidas Biotech, Inc’s variety of dye materials.) Introducing these probes into the systems of small animals enables researchers to see more in terms of pathophysiological processes. The goal is in evaluating the biodistribution, pharmacokinetics and biological activity of potentially therapeutics molecules that will identify and fight tumours. Deep tissue molecular imaging with diffraction limited resolution at the single cell level can also facilitate basic research in biology and medicine. But to do so efficiently requires a SWIR optimised camera.

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