1.  Home
  2. Whitepapers
  3. Application of Low- and Mid-Frequency Raman Spectroscopy to Characterize the Amorphous-Crystalline Transformation of Indomethacin

Application of Low- and Mid-Frequency Raman Spectroscopy to Characterize the Amorphous-Crystalline Transformation of Indomethacin

Download Whitepaper

Application of Low- and Mid-Frequency Raman Spectroscopy to Characterize the Amorphous-Crystalline Transformation of Indomethacin

Download Whitepaper
  • Author: Peter J. Larkin, John Wasylyk, Michaella Raglione
Raman spectroscopy using the mid-frequency (1800–1500 cm1) and low-frequency (200–8 cm1) spectral regions is used to study the transformation of amorphous indomethacin (IND) to the ccrystalline form. The low-frequency spectral region provides access to collective vibrations of molecules in the crystalline and amorphous state, while the mid-frequency spectral region provides access to the molecular vibrations that are sensitive to the local functional group environment.

Download Whitepaper Now