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Cell-Based Fluorescent Assay for Selectivity Evaluation between Two Na+ Channels Subtypes

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Cell-Based Fluorescent Assay for Selectivity Evaluation between Two Na+ Channels Subtypes

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Sodium voltage gated ion channels (Nav 1.x) are expressed in central neurons. Certain subtypes have been implicated in different forms of epilepsy and as such, have been targets in the development of anti-epileptic drugs. Very few methods are available to study voltage gated ion channels in high throughput which has impaired drug discovery for epilepsy. We describe here a fluorescence method, scalable in high throughput, based on the use of SBFI dye (e.g. invitrogen) in the Hamamatsu FDSS6000 screening system.

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