1.  Home
  2. Whitepapers
  3. CoroNa Red as a Potential Probe for Intracellular Sodium Imaging

CoroNa Red as a Potential Probe for Intracellular Sodium Imaging

Download Whitepaper

CoroNa Red as a Potential Probe for Intracellular Sodium Imaging

Download Whitepaper
We have examined the new sodium indicator fluorescent dye named CoroNa Red using FDSS. Molecular Probe newest Na+ indicator is CoroNa Red chloride, which is based on a crown ether that has structural similarity to the Ca2+ chelator BAPTA. Unlike SBFI and Sodium Green, the net positive charge of CoroNa Red targets the indicator to mitochondria and loading of cells does not require use of a permeant ester derivative of the dye. weakly fluorescent in the absence of Na+ and its fluorescence increases ~15-fold upon binding Na+. Despite its relatively high Kd for Na+ of ~200 mM (Table. 1), CoroNa Red indicator exhibits sensitive responses to cellular Na+ influxes through voltage-gated channels and ATP-gated cation pores

Download Whitepaper Now