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FRET-based Voltage Sensor Dyes for Drug Screening

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FRET-based Voltage Sensor Dyes for Drug Screening

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Voltage-sensitive FRET offers the several significant advantages over traditional voltage-sensitive dyes for biological and pharmaceutical screening applications. The voltage sensitive FRET sensor is composed of two fluorescent components. The first is the highly fluorescent, negatively charged hydrophobic ion that "senses" the trans-membrane electrical potential. It rapidly redistributes between two binding sites on opposite sites of the plasma membrane in the Nernstain manner. In response to a membrane potential charge, the hydrophobic ions translocate across the membrane and establish a new equilibrium corresponding to the new membrane potential.

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