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Real time imaging of mitochondrial ATP levels under hypoxic conditions using a FRET biosensor

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Real time imaging of mitochondrial ATP levels under hypoxic conditions using a FRET biosensor

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Cardiomyocytes are rich in mitochondria to meet a high demand for adenosine triphosphate (ATP) by heart, and it has been suggested that dysfunction of mitochondria and heart disease are closely related. In addition, the heart of patients with cardiac disease is susceptible to injury from hypoxia, and one of the causes of injury is oxidative phosphorylation (OXPHOS) in the mitochondria, which has a high oxygen demand for ATP synthesis, has been inhibited by hypoxia. Real-time observation of how ATP synthesis in cardiomyocytes is affected by hypoxia could be very useful in the development of for therapeutic agents for heart disease.

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