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Live cell microscopy for long term observation of mitosis by spinning disk confocal, CSU-W1

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Live cell microscopy for long term observation of mitosis by spinning disk confocal, CSU-W1

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Long-term observation of mitosis by live-cell microscopy is required for uncovering the role of Cohesin on compartmentalized nuclear architecture which is linked to nuclear functions. To perform long-term observation of mitosis devices are needed that have low phototoxic effects on living cells and enable high speed imaging. Cohesin, a ring-like protein complex with its major subunits RAD21, SMC1, and SMC3 is involved in sister chromatid entrapment to ensure proper chromosome segregation during mitosis, in double-strand break repair and gene regulation. Its impact on a compartmentalized nuclear architecture, linked to nuclear functions, is less well understood.

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