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Quantitative Analysis of ?H2AX Granule induced by DNA damage

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Quantitative Analysis of ?H2AX Granule induced by DNA damage

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DNA is under continuous genotoxic stresses from variety of environmental factors and cells have mechanisms to repair damaged DNA. The DNA repair machinery can be visualized as the granules in the nucleus by labeling proteins contained in the protein complex formed around the damaged part of DNA. Quantitative analysis of these granules is essential in the research fields such as anticancer agent, influence of radiation, monitoring the genotoxicity of environmental chemicals including tobacco ingredients, and the basic research of cell cycle and DNA repair mechanisms as well. This application note offers an example of the analysis of granules in the nucleus with CQ1.

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