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Light Delivery Optimization for H&N Cancer Treatment

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Light Delivery Optimization for H&N Cancer Treatment

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Head & neck cancer comprises several different malignant tumors that develop in the throat, larynx, nasal cavity, sinuses, lips, or mouth. Patients with refractory H&N cancer have poor prognosis, with response rates being less than 40% for chemotherapy and less than 20% for newer immunotherapies. Cure rates also remain poor with irradiation or salvage surgery. Interstitial photodynamic therapy (iPDT) is a promising treatment for H&N cancer where optical fibers are placed within the target tumor to deliver deep intratumoral illumination for bulky diseases. It is approved in Europe for palliation of patients with advanced, refractory H&N cancer using temoporfin as a photosensitizer, while Photofrin® has been approved for other indications in USA and is being studied for H&N cancer.

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