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Antimicrobial PDT for Prosthetic Joint Infections

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Antimicrobial PDT for Prosthetic Joint Infections

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Methylene blue was demonstrated to be an effective antimicrobial agent when combined with 665 nm laser light, while without the laser light, it had very limited efficacy. Increasing the laser dose increased the bactericidal effect, with a dose of 35 J/cm2 being the lowest laser dose to eradicate all bacteria. This optimized treatment protocol should be next studied in vivo before being used in a human clinical trial. Antimicrobial PDT may become a beneficial and safe treatment for prosthetic joint infections in the future due to its speed of action and lack of bacterial resistance.

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