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Combining Photoimmunotherapy with Immune Checkpoint Inhibition

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Combining Photoimmunotherapy with Immune Checkpoint Inhibition

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Photoimmunotherapy is a new class of molecular-targeted cancer therapy which was invented by Dr. Kobayashi. It is based on photoabsorber IRDye700 conjugated to a monoclonal antibody (mAb) against a surface antigen selectively expressed on cancer cells. Conjugate-bound cancer cells are rapidly and selectively killed upon NIR light illumination with a 689 nm laser. This type of therapy also induces a strong immune response by immunogenic release of tumor antigens from the damaged cancer cells.

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