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Human Mesenchymal Stem Cell Growth on Corning® Denatured Collagen-coated Dissolvable Microcarriers in a 5L Bioreactor

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Human Mesenchymal Stem Cell Growth on Corning® Denatured Collagen-coated Dissolvable Microcarriers in a 5L Bioreactor

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  • Author: Jennifer Weber, Lori Romeo, Paula Dolley-Sonneville
Microcarriers are 100 to 300 micron-sized beads that support the attachment and growth of adherent cells in stirred culture. They enable more cost-effective cell production by reducing the fixed costs (e.g., footprint and labor) and variable costs (e.g., media consumption) in large-scale manufacturing. One challenge associated with microcarrier-based expansion is that microcarriers eventually must be removed or separated from the final product.

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