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Photo-Biological Testing With UV Solar Simulators

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Photo-Biological Testing With UV Solar Simulators

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Photo-biology is the study of the effect of UVA and/or UVB, visible, and IR radiation upon living systems. The first law of photochemistry (Grotthaus-Draper Law) states that light must be absorbed for a photochemical event to occur. Chromophores in drug products and DNA in dermal tissue are targets for photochemical reactions. Photoirritation and/or photoallergy occur when a photoactive chemical enters the skin by dermal penetration or systemic circulation and becomes excited by appropriate UV or visible light photons. Photo safety testing is suggested for any chemicals that absorb light in the range from 290-700nm for any substance that may be applied topically or can reach the skin and/or eyes by systemic exposure (oral or intravenous).

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